Issue 44, 2010
From the journal:

Chemical Communications

Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)†‡

Hee-Kyung Kim,b   Ji-Ae Park,c   Kyeong Min Kim,c   Nasiruzzaman Sk Md.,a   Duk-Sik Kang,d   Jongmin Lee,d   Yongmin Chang*be  and  Tae-Jeong Kim*a  

* Corresponding authors

a Department of Applied Chemistry, Kyungpook National University, Daegu, Korea
E-mail: tjkim@knu.ac.kr
Tel: +82 53-950-5587

b Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea
E-mail: ychang@knu.ac.kr
Tel: +82 53-950-5587

c Laboratory of Nuclear Medicine Research, Molecular Imaging Research Center, Korea Institute of Radiological Medical Science, Seoul, Korea

d Department of Diagnostic Radiology, School of Medicine, Kyungpook National University, Daegu, Korea

e Department of Diagnostic Radiology & Molecular Medicine, Kyungpook National University, Daegu, Korea

Abstract

We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a–b) and their Gd-complexes [Gd(L)(H2O)] (2a–b, L = 1a–b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

Graphical abstract: Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

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Article information

DOI
https://doi.org/10.1039/C0CC03145C
Article type
Communication
Submitted
10 Aug 2010
Accepted
13 Sep 2010
First published
01 Oct 2010

Chem. Commun., 2010,46, 8442-8444

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Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

H. Kim, J. Park, K. M. Kim, N. Sk Md., D. Kang, J. Lee, Y. Chang and T. Kim, Chem. Commun., 2010, 46, 8442 DOI: 10.1039/C0CC03145C

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