Issue 11, 2010
From the journal:

Natural Product Reports

Kdo: a critical monosaccharide for bacteria viability

Laura Cipolla,*a   Luca Gabrielli,a   Davide Bini,a   Laura Russoa  and  Nasrin Shaikha  

* Corresponding authors

a Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, P.za della Scienza 2, Milano, Italy
E-mail: laura.cipolla@unimib.it
Fax: +39 0264483565
Tel: +39 0264483460

Abstract

Covering: 2000 to 2010

Kdo belongs to the 3-deoxysugar ‘family’ and is a critical monosaccharidic component of lipopolysaccharides (LPSs) in Gram-negative bacteria. The incorporation of Kdo into LPSs is a vital step in the assembly of the protective outer membrane of Gram-negative bacteria. This review intends to present recent advances on structural/biocatalytic knowledge on the four enzymes involved in Kdo metabolism, and on the synthesis and biological activity of analogues of biosynthetic intermediates, highlighting the potential of this pathway for the discovery of new antibacterials – a pressing need due to the emergence of new classes of antibiotic-resistant bacteria.

Graphical abstract: Kdo: a critical monosaccharide for bacteria viability

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Article information

DOI
https://doi.org/10.1039/C004750N
Article type
Review Article
Submitted
28 Jul 2010
First published
29 Sep 2010

Nat. Prod. Rep., 2010,27, 1618-1629

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Kdo: a critical monosaccharide for bacteria viability

L. Cipolla, L. Gabrielli, D. Bini, L. Russo and N. Shaikh, Nat. Prod. Rep., 2010, 27, 1618 DOI: 10.1039/C004750N

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