Issue 6, 2009
From the journal:

Analyst

Vibrational spectroscopy: a clinical tool for cancer diagnostics†

Catherine Kendall,a   Martin Isabelle,a   Florian Bazant-Hegemark,a   Joanne Hutchings,a   Linda Orr,a   Jaspreet Babrah,a   Rebecca Bakera  and  Nicholas Stone*a  

* Corresponding authors

a Biophotonics Research Unit, Leadon House, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK
E-mail: n.stone@medical-research-centre.com
Fax: +44 (0)8454 225485
Tel: +44 (0)8454 225486

Abstract

Vibrational spectroscopy techniques have demonstrated potential to provide non-destructive, rapid, clinically relevant diagnostic information. Early detection is the most important factor in the prevention of cancer. Raman and infrared spectroscopy enable the biochemical signatures from biological tissues to be extracted and analysed. In conjunction with advanced chemometrics such measurements can contribute to the diagnostic assessment of biological material. This paper also illustrates the complementary advantage of using Raman and FTIR spectroscopy technologies together. Clinical requirements are increasingly met by technological developments which show promise to become a clinical reality. This review summarises recent advances in vibrational spectroscopy and their impact on the diagnosis of cancer.

Graphical abstract: Vibrational spectroscopy: a clinical tool for cancer diagnostics

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Article information

DOI
https://doi.org/10.1039/B822130H
Article type
Critical Review
First published
23 Mar 2009

Analyst, 2009,134, 1029-1045

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Vibrational spectroscopy: a clinical tool for cancer diagnostics

C. Kendall, M. Isabelle, F. Bazant-Hegemark, J. Hutchings, L. Orr, J. Babrah, R. Baker and N. Stone, Analyst, 2009, 134, 1029 DOI: 10.1039/B822130H

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