Issue 1, 2011

DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology

Abstract

Oligonucleotides have recently gained increased attraction as a supramolecular scaffold for the design and synthesis of functional molecules on the nanometre scale. This tutorial review focuses on the recent progress in this highly active field of research with an emphasis on covalent modifications of DNA; non-covalent interactions of DNA with molecules such as groove binders or intercalators are not part of this review. Both terminal and internal modifications are covered, and the various points of attachment (nucleobase, sugar moiety or phosphodiester backbone) are compared. Using selected examples of the recent literature, the diversity of the functionalities that have been incorporated into DNA strands is discussed.

Graphical abstract: DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology

Article information

Article type
Tutorial Review
Submitted
22 Dec 2009
First published
09 Aug 2010

Chem. Soc. Rev., 2011,40, 138-148

DNA as supramolecular scaffold for functional molecules: progress in DNA nanotechnology

T. J. Bandy, A. Brewer, J. R. Burns, G. Marth, T. Nguyen and E. Stulz, Chem. Soc. Rev., 2011, 40, 138 DOI: 10.1039/B820255A

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