Issue 16, 2009
From the journal:

Journal of Materials Chemistry

Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug†

Chiyoung Park,‡a   Hyewon Youn,‡b   Hana Kim,a   Taiho Noh,a   Yeon Hee Kook,a   Eun Tax Oh,a   Heon Joo Park*b  and  Chulhee Kim*a  

* Corresponding authors

a Department of Polymer Science and Engineering, Inha University, Incheon, Korea
E-mail: chk@inha.ac.kr
Fax: +82-32-865-5178
Tel: +82-32-860-7487

b Department of Microbiology, Center for Advanced Medical Education by BK21 Project, College of Medicine, Inha University, Incheon, Korea
E-mail: park001@inha.ac.kr

Abstract

We report on the therapeutic ability of a novel cyclodextrin-covered gold nanoparticle (AuNP) carrier for noncovalent encapsulation of an anti-cancer drug. The surface of the AuNPs was functionalized with cyclodextrin as a drug pocket, anti-epidermal growth factor receptor (anti-EGFR) antibody as a targeting moiety, and poly(ethyleneglycol) (PEG) as an anti-fouling shell. β-Lapachone, an anti-cancer drug, was efficiently encapsulated into the hydrophobic cavity of cyclodextrin on the surface of the AuNP carriers (AuNP-1). The glutathione-mediated release of β-lapachone from the surface of AuNP-1 was demonstrated by an experiment with MCF-7 (low glutathione concentration) and A549 cells (high glutathione concentration). We also show that the introduction of an anti-EGFR antibody onto the AuNP carriers (AuNP-2) increased the intracellular uptake of AuNP carriers as compared with AuNP-1, which does not contain a targeting ligand. In the in vitro cytotoxicity study, AuNP-2 with β-lapachone exhibited a higher apoptosis effect than that caused by AuNP-1 with β-lapachone. This work suggests that AuNPs covered with cyclodextrin and tumor-targeting ligands may find useful applications for the development of nanoparticles with therapeutic and diagnostic modalities.

Graphical abstract: Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

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Article information

DOI
https://doi.org/10.1039/B816209C
Article type
Paper
Submitted
16 Sep 2008
Accepted
12 Jan 2009
First published
27 Feb 2009

J. Mater. Chem., 2009,19, 2310-2315

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Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

C. Park, H. Youn, H. Kim, T. Noh, Y. H. Kook, E. T. Oh, H. J. Park and C. Kim, J. Mater. Chem., 2009, 19, 2310 DOI: 10.1039/B816209C

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