Issue 22, 2008

Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells

Abstract

Studies on the sensitization, by novel alkynyl luteolin analogues, of TNF-α-induced apoptosis in HeLa and HepG2 cells revealed that LA-12 showed better sensitizing effects on TNF-α-induced cell death than luteolin, suggesting great potential for alkynyl luteolin analogues in cancer therapy.

Graphical abstract: Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells

Supplementary files

Article information

Article type
Communication
Submitted
12 Aug 2008
Accepted
24 Sep 2008
First published
09 Oct 2008

Org. Biomol. Chem., 2008,6, 4102-4104

Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-α-induced apoptosis in human tumor cells

L. Cheng, H. Tan, X. Wu, R. Hu, C. Aw, M. Zhao, H. Shen and Y. Lu, Org. Biomol. Chem., 2008, 6, 4102 DOI: 10.1039/B813904K

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