Issue 39, 2008
From the journal:

Chemical Communications

Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs†

Cynthia Demicheli,*a   Frédéric Frézard,b   John B. Mangrumc  and  Nicholas P. Farrell*c  

* Corresponding authors

a Departamento de Química, ICEX, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
E-mail: demichel@dedalus.lcc.ufmg.br
Fax: +55 3134095700
Tel: +55 3134095755

b Departamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
E-mail: frezard@icb.ufmg.br
Fax: +55 3134092924
Tel: +55 3134092940

c Department of Chemistry, Virginia Commonwealth University, 1001 W. Main Street, Richmond, USA
E-mail: npfarrell@vcu.edu
Fax: +1 804 828 8599
Tel: +1 804 828 6320

Abstract

SbIII competes with ZnII for its binding to the CCHC zinc finger domain of the NCp7 protein of HIV-1, indicating that zinc finger proteins may be targets for antimony-based drugs and thus responsible for their important pharmacological actions.

Graphical abstract: Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs

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Article information

DOI
https://doi.org/10.1039/B809186B
Article type
Communication
Submitted
02 Jun 2008
Accepted
10 Jul 2008
First published
26 Aug 2008

Chem. Commun., 2008, 4828-4830

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Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs

C. Demicheli, F. Frézard, J. B. Mangrum and N. P. Farrell, Chem. Commun., 2008, 4828 DOI: 10.1039/B809186B

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