Issue 29, 2008
From the journal:

Chemical Communications

Single base interrogation by a fluorescent nucleotide: each of the four DNA bases identified by fluorescence spectroscopy†

Pavol Cekana  and  Snorri Th. Sigurdsson*a  

* Corresponding authors

a University of Iceland, Science Institute, Dunhaga 3, 107 Reykjavik, Iceland
E-mail: snorrisi@hi.is
Fax: +354 5528911
Tel: +354 5254801

Abstract

Nucleoside Ç, which contains a rigid nitroxide spin label, is effectively reduced in DNA by sodium sulfide to the corresponding amine, yielding a fluorescent probe (Çff) that can report the identity of its base-pairing partner in duplex DNA.

Graphical abstract: Single base interrogation by a fluorescent nucleotide: each of the four DNA bases identified by fluorescence spectroscopy

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Article information

DOI
https://doi.org/10.1039/B801833B
Article type
Communication
Submitted
01 Feb 2008
Accepted
15 May 2008
First published
05 Jun 2008

Chem. Commun., 2008, 3393-3395

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Single base interrogation by a fluorescent nucleotide: each of the four DNA bases identified by fluorescence spectroscopy

P. Cekan and S. Th. Sigurdsson, Chem. Commun., 2008, 3393 DOI: 10.1039/B801833B

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