Issue 24, 2007
From the journal:

Organic & Biomolecular Chemistry

Nitroxyl radicals: electrochemical redox behaviour and structure–activity relationships†

Sushma Manda,a   Ikuo Nakanishi,ab   Kei Ohkubo,b   Haruko Yakumaru,c   Ken-ichiro Matsumoto,a   Toshihiko Ozawa,ad   Nobuo Ikota,e   Shunichi Fukuzumib  and  Kazunori Anzai*a  

* Corresponding authors

a Radiation Modifier Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555, Japan
E-mail: anzai@nirs.go.jp
Fax: +81-43-255-6819
Tel: +81-43-206-3125

b Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Suita, Osaka 565-0871, Japan

c Mechanism Research Team, Medical Treatment for High Dose Exposure Research Group, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555, Japan

d Yokohama College of Pharmacy, Yokohama 245-0066, Japan

e School of Pharmacy, Shujitsu University, Okayama 703-8516, Japan

Abstract

Comparative study of electrochemical redox behaviour of five different nitroxyl radicals leads to the direct correlation between one-electron redox potentials and group electronegativity of the β-substituent on the ring. β-Substituents with an electron-donating effect caused a negative shift in the one-electron oxidation and one-electron reduction potentials of the nitroxyl radicals. In a similar aspect, β-substituents with an electron-withdrawing effect behaved oppositely.

Graphical abstract: Nitroxyl radicals: electrochemical redox behaviour and structure–activity relationships

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Article information

DOI
https://doi.org/10.1039/B714765A
Article type
Paper
Submitted
25 Sep 2007
Accepted
11 Oct 2007
First published
31 Oct 2007

Org. Biomol. Chem., 2007,5, 3951-3955

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Nitroxyl radicals: electrochemical redox behaviour and structure–activity relationships

S. Manda, I. Nakanishi, K. Ohkubo, H. Yakumaru, K. Matsumoto, T. Ozawa, N. Ikota, S. Fukuzumi and K. Anzai, Org. Biomol. Chem., 2007, 5, 3951 DOI: 10.1039/B714765A

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