Issue 2, 2007
From the journal:

Organic & Biomolecular Chemistry

Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking†

Daniela Verga,a   Sara N. Richter,b   Manlio Palumbo,b   Remo Gandolfia  and  Mauro Freccero*a  

* Corresponding authors

a Dipartimento di Chimica Organica, Università di Pavia, V.le Taramelli 10, 27100 Pavia, Italy
E-mail: mauro.freccero@unipv.it

b Dipartimento di Scienze Farmaceutiche, Università di Padova, Via Marzolo 5, 35131 Padova, Italy
E-mail: sara.richter@unipd.it

Abstract

The photoactivation of 6,6′-bis-CH2X-[2,2′]bipyridinyl-5,5′-diol ligands as mono and bis-alkylating agents has been investigated, detecting transient heterocyclic quinone methides.

Graphical abstract: Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking

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Article information

DOI
https://doi.org/10.1039/B616292D
Article type
Communication
Submitted
07 Nov 2006
Accepted
08 Nov 2006
First published
16 Nov 2006

Org. Biomol. Chem., 2007,5, 233-235

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Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking

D. Verga, S. N. Richter, M. Palumbo, R. Gandolfi and M. Freccero, Org. Biomol. Chem., 2007, 5, 233 DOI: 10.1039/B616292D

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