Issue 21, 2007
From the journal:

Chemical Communications

Stereochemistry of rHint1 hydrolase assisted cleavage of P–N bond in nucleoside 5′-O-phosphoramidothioates†

Agnieszka Krakowiak,a   Renata Kaczmarek,a   Janina Baraniak,a   Michał Wieczorekb  and  Wojciech J. Stec*a  

* Corresponding authors

a Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., Poland
E-mail: wjstec@bio.cbmm.lodz.pl
Fax: (+48) 42-681-54-83
Tel: (+48) 42-680-32-20

b Institute of Chemistry and Environmental Protection, Pedagogical University of Częstochowa, AL. Armii Krajowej 13/15, Poland

Abstract

The Hint-1 hydrolase assisted cleavage of the P–N bond in adenosine-5′-O-[N-(tryptophanylamide)]phosphoramidothioate proceeds with retention of configuration at the phosphorus atom which is consistent with the formation of a covalent enzyme–substrate complex.

Graphical abstract: Stereochemistry of rHint1 hydrolase assisted cleavage of P–N bond in nucleoside 5′-O-phosphoramidothioates

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Article information

DOI
https://doi.org/10.1039/B615160D
Article type
Communication
Submitted
18 Oct 2006
Accepted
01 Feb 2007
First published
22 Feb 2007

Chem. Commun., 2007, 2163-2165

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Stereochemistry of rHint1 hydrolase assisted cleavage of P–N bond in nucleoside 5′-O-phosphoramidothioates

A. Krakowiak, R. Kaczmarek, J. Baraniak, M. Wieczorek and W. J. Stec, Chem. Commun., 2007, 2163 DOI: 10.1039/B615160D

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