RSC Publishing


Publishing

 

Cover image for Chemical Communications, click here for current issue

Chemical Communications

Urgent high quality communications from across the chemical sciences.



Subscribers

  • PDF
  • HTML article

Non-subscribers

Free access



Communication

Chem. Commun., 2007, 948 - 950, DOI: 10.1039/b614958h

Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

Shinji Harada, Ryo Takita, Takashi Ohshima, Shigeki Matsunaga and Masakatsu Shibasaki

Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2–10 mol% of catalyst.

Graphical abstract image for this article (ID: b614958h)