Issue 10, 2007
From the journal:

Chemical Communications

Trichlorophenol (TCP) sulfonate esters: A selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides†

Jonathan D. Wilden,*a   Lynsey Geldeard,a   Chieh C. Lee,a   Duncan B. Juddb  and  Stephen Caddick*a  

* Corresponding authors

a The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: j.wilden@ucl.ac.uk, s.caddick@ucl.ac.uk

b GlaxoSmithKline, Third Avenue, Harlow, Essex, UK

Abstract

2,4,6-Trichlorophenol (TCP) sulfonate esters undergo effective aminolysis under conventional heating and microwave irradiation; the reactivity of these species is such that chemoselective transformations of PFP sulfonate esters can be achieved.

Graphical abstract: Trichlorophenol (TCP) sulfonate esters: A selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides

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Article information

DOI
https://doi.org/10.1039/B614604J
Article type
Communication
Submitted
09 Oct 2006
Accepted
22 Nov 2006
First published
21 Dec 2006

Chem. Commun., 2007, 1074-1076

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Trichlorophenol (TCP) sulfonate esters: A selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides

J. D. Wilden, L. Geldeard, C. C. Lee, D. B. Judd and S. Caddick, Chem. Commun., 2007, 1074 DOI: 10.1039/B614604J

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