Issue 30, 2006
From the journal:

Journal of Materials Chemistry

Biomimetic core–shell gelatine/silicananoparticles: a new example of biopolymer-based nanocomposites†

Joachim Allouche,a   Michel Boissière,ab   Christophe Hélary,a   Jacques Livageab  and  Thibaud Coradin*a  

* Corresponding authors

a Chimie de la Matière Condensée de Paris, CNRS UMR 7574, Université Pierre et Marie Curie, 75252 Paris cedex 05, France
E-mail: coradin@ccr.jussieu.fr
Fax: 33 1 44 27 47 69
Tel: 33 1 44 27 47 69

b Collège de France, 11 place Marcellin Berthelot, 75005 Paris, France

Abstract

Hybrid nanoparticles have great potential for biotechnological and biomedical applications. It was recently proposed that biopolymer/silica nanomaterials could be easily obtained by adapting traditional routes used in pharmaceutical science to design polymer nanoparticles. In this paper, we demonstrate that core–shell gelatine/silica nanoparticles can be obtained using a nano-emulsion route, taking advantage of the thermal gelation properties of the biopolymer and of its strong “biomimetic” affinity for silicates. The formation of the silica coating could be ascertained by SEM, TEM, EDAX, FTIR and DLS/zeta potential measurements. Silica coating was also performed on microparticles, allowing us to investigate in more detail the mechanism of silica deposition on the gelatine surface, which bears some relevance for the understanding of biosilicification processes. Finally, the possible internalization and intracellular degradation of these hybrid nanoparticles by fibroblast cells was demonstrated. A comparison with previously described silica/alginate nanoparticles is provided in the context of drug-delivery system design.

Graphical abstract: Biomimetic core–shell gelatine/silica nanoparticles: a new example of biopolymer-based nanocomposites

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Article information

DOI
https://doi.org/10.1039/B604366F
Article type
Paper
Submitted
24 Mar 2006
Accepted
31 May 2006
First published
15 Jun 2006

J. Mater. Chem., 2006,16, 3120-3125

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Biomimetic core–shell gelatine/silica nanoparticles: a new example of biopolymer-based nanocomposites

J. Allouche, M. Boissière, C. Hélary, J. Livage and T. Coradin, J. Mater. Chem., 2006, 16, 3120 DOI: 10.1039/B604366F

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