Issue 10, 2006
From the journal:

Organic & Biomolecular Chemistry

A paramagnetic contrast agent with myeloperoxidase-sensing properties†

Manel Querol,a   John W. Chenb  and  Alexei A. Bogdanov, Jr.*a  

* Corresponding authors

a S2-804, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts, USA
E-mail: Alexei.Bogdanov@umassmed.edu

b Centre for Molecular Imaging Research at Massachusetts General Hospital Bldg 149, 13th Street, Charlestown, Massachusetts, USA

Abstract

Myeloperoxidase (MPO) is an essential component of inflammatory response in norm and pathology. With an ultimate goal of non-invasive imaging of MPO we used a gadolinium-chelating bis(5-hydroxytrytamide) derivative of diethylenetetraamine pentaacetic acid (L1–Gd3+salt) as a paramagnetic sensor of enzymatic activity. We tested whether L1–Gd3+ is active in reducing the oxidized form of myeloperoxidase, generated as a result of hydrogen peroxide reduction by the enzyme. We expected that upon activation by MPO/H2O2 L1–Gd3+ would not only oligomerise but also bind to other macromolecules present in the media and that the overall process will give rise to a net T1-weighted MRI signal increase.

Graphical abstract: A paramagnetic contrast agent with myeloperoxidase-sensing properties

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Article information

DOI
https://doi.org/10.1039/B601540A
Article type
Paper
Submitted
01 Feb 2006
Accepted
16 Mar 2006
First published
12 Apr 2006

Org. Biomol. Chem., 2006,4, 1887-1895

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A paramagnetic contrast agent with myeloperoxidase-sensing properties

M. Querol, J. W. Chen and A. A. Bogdanov, Jr., Org. Biomol. Chem., 2006, 4, 1887 DOI: 10.1039/B601540A

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