Issue 11, 2005
From the journal:

Journal of Environmental Monitoring

The study of age influence on human bone lead metabolism by using a simplified model and X-ray fluorescence data

Huiling Nie,*a   David R. Chettle,a   Colin E. Webber,b   José A. A. Brito,c   Joanne M. O’Mearad  and  Fiona E. McNeilla  

* Corresponding authors

a Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, Canada
E-mail: nieh@mcmaster.ca

b Department of Nuclear Medicine, Hamilton Health Sciences, Hamilton, Canada

c Department of Mathematics, Physics and Computer Science, Ryerson University, Toronto, Canada

d Department of Physics, University of Guelph, Guelph, Canada

Abstract

Long term lead metabolism in the human body has never been fully understood due to the lack of human data in this area. The technological improvement of bone lead measurement systems has made bone lead data of substantial populations available. In this study, a set of X-ray fluorescence bone lead data was used to test Leggett’s lead metabolism model (R. W. Leggett, Environ. Health Perspect., 1993a, 101, 598–616), especially the model of metabolism in bone. The data set includes the bone lead concentration of 539 occupationally exposed workers, of whom 327 were measured twice in five years. The bone lead concentrations of both cortical bone (tibia) and trabecular bone (calcaneus) were obtained by Cd-109 γ-ray induced XRF measurement. The histories of blood lead concentration for these workers were used to regulate the input file of the model. The results show that the bone lead concentrations predicted by Leggett’s model greatly underestimate the measured values, especially for older workers. This data set was then organized into five age groups. A new simplified model was applied to estimate the lead transfer rates between blood and lead compartments for these age groups. The original transfer rates and the new transfer rates are compared, and the differences are discussed. When the transfer rates derived from measured bone lead data were put into the input file of the model to replace the existing parameters, the predicted values were much closer to the measured values for both cortical bone and trabecular bone.

Graphical abstract: The study of age influence on human bone lead metabolism by using a simplified model and X-ray fluorescence data

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Article information

DOI
https://doi.org/10.1039/B507749D
Article type
Paper
Submitted
01 Jun 2005
Accepted
26 Aug 2005
First published
30 Sep 2005

J. Environ. Monit., 2005,7, 1069-1073

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The study of age influence on human bone lead metabolism by using a simplified model and X-ray fluorescence data

H. Nie, D. R. Chettle, C. E. Webber, J. A. A. Brito, J. M. O’Meara and F. E. McNeill, J. Environ. Monit., 2005, 7, 1069 DOI: 10.1039/B507749D

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