Issue 8, 2005
From the journal:

Green Chemistry

Ionic liquids as additives in the pig liver esterase (PLE) catalysed synthesis of chiral disubstituted malonates

Stefan Wallert,ab   Karlheinz Drauz,*a   Ian Grayson,c   Harald Gröger,d   Pablo Dominguez de Mariad  and  Carsten Bolm*b  

* Corresponding authors

a Degussa AG, Exclusive Synthesis & Catalysts, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany

b RWTH-Aachen, Institut für Organische Chemie, Landoltweg 1, 52056 Aachen, Germany

c Degussa AG, Exclusive Synthesis & Catalysts, Seal Sands, Middlesbrough, TS2 1UB, UK

d Degussa AG, Service Center Biocatalysis, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany

Abstract

This report describes the first application of hydroxylated and epoxylated ionic liquids as additives in the enantioselective hydrolysis of prochiral diester malonates using pig liver esterase (PLE) as catalyst. Less than 1% of a hydrophilic functionalised ionic liquid, used in combination with 10% isopropanol/water is sufficient to enhance the activity of the enzyme by a factor of up to 4 and also to increase the enantioselectivity of the reaction. Immobilisation of the PLE on Eupergit® C enabled successful recycling of the enzyme system.

Graphical abstract: Ionic liquids as additives in the pig liver esterase (PLE) catalysed synthesis of chiral disubstituted malonates

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Article information

DOI
https://doi.org/10.1039/B503010B
Article type
Paper
Submitted
01 Mar 2005
Accepted
04 May 2005
First published
25 May 2005

Green Chem., 2005,7, 602-605

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Ionic liquids as additives in the pig liver esterase (PLE) catalysed synthesis of chiral disubstituted malonates

S. Wallert, K. Drauz, I. Grayson, H. Gröger, P. Dominguez de Maria and C. Bolm, Green Chem., 2005, 7, 602 DOI: 10.1039/B503010B

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