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Green Chem., 2004, 6, 219 - 221, DOI: 10.1039/b401620c

Aqueous N-alkylation of amines using alkyl halides: direct generation of tertiary amines under microwave irradiation

Yuhong Ju and Rajender S. Varma

Direct formation of tertiary amines viaN-alkylation of amines by alkyl halides occurs in aqueous media under microwave irradiation. This greener alternative is also a useful and powerful method to construct C–N bond without using any transition metal catalysts.

Graphical abstract image for this article (ID: b401620c)