Issue 14, 2003
From the journal:

Chemical Communications

Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine

Gyoung-Dong Kang,a   Philip W. Howard*a  and  David E. Thurston*a  

* Corresponding authors

a Cancer Research UK Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK
E-mail: gene.targeting@ulsop.ac.uk
Fax: +44 0207-753-5935
Tel: +44 0207-753-5932

Abstract

A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.

Graphical abstract: Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine

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Article information

DOI
https://doi.org/10.1039/B303274D
Article type
Communication
Submitted
26 Mar 2003
Accepted
20 May 2003
First published
11 Jun 2003

Chem. Commun., 2003, 1688-1689

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Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine

G. Kang, P. W. Howard and D. E. Thurston, Chem. Commun., 2003, 1688 DOI: 10.1039/B303274D

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