Issue 9, 2002
From the journal:

Analyst

Square wave voltammetric sensing of uric acid using the self-assembly of mercaptobenzimidazole

C. Retna Raj,a   F. Kitamuraa  and  Takeo Ohsaka*a  

* Corresponding authors

a Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502, Japan
E-mail: ohsaka@echem.titech.ac.jp
Fax: +81-045-924-5489
Tel: +81-045-924-5404

Abstract

The self-assembled monolayer of a heterocyclic thiol, mercaptobenzimidazole (MBI) on gold (Au) electrode is successfully utilized for the voltammetric sensing of uric acid (UA). The self-assembly of MBI separates the voltammetric signal of UA from the interfering ascorbate (AA). Selective detection of UA in the presence of a large excess of AA or the simultaneous detection of UA and AA is achieved at the MBI monolayer-modified electrode. This electrode can detect as low as 1 μM of UA in the presence of 100-fold excess of AA with excellent reproducibility. The practical utility of the electrode is demonstrated by measuring the concentration of UA in human serum.

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Article information

DOI
https://doi.org/10.1039/B206703J
Article type
Communication
Submitted
10 Jul 2002
Accepted
30 Jul 2002
First published
13 Aug 2002

Analyst, 2002,127, 1155-1158

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Square wave voltammetric sensing of uric acid using the self-assembly of mercaptobenzimidazole

C. R. Raj, F. Kitamura and T. Ohsaka, Analyst, 2002, 127, 1155 DOI: 10.1039/B206703J

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