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Lab on a Chip

Microfluidic and nanotechnologies for chemistry, biology, and bioengineering



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Paper

Lab Chip, 2002, 2, 141 - 144, DOI: 10.1039/b203977j

Investigation of racemisation in peptide synthesis within a micro reactor

Paul Watts, Charlotte Wiles, Stephen J. Haswell and Esteban Pombo-Villar

We demonstrate that peptides derived from -amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.