Issue 21, 2001
From the journal:

Physical Chemistry Chemical Physics

The effect of hydrophobe chemical structure and chain length on the solubilization of griseofulvin in aqueous micellar solutions of block copoly(oxyalkylene)s

Christopher J. Rekatas,a   Shao-Min Mai,a   Michael Crothers,b   Martin Quinn,b   John H. Collett,b   David Attwood,*b   Frank Heatley,a   Luigi Martinic  and  Colin Bootha  

* Corresponding authors

a Department of Chemistry, Uniersity of Manchester, Manchester, UK

b School of Pharmacy and Pharmaceutical Sciences, Uniersity of Manchester, Manchester, UK
E-mail: David.Attwood@man.ac.uk
Fax: Fax: + 44 (0)161 275 2396
Tel: Tel: + 44 (0)161 275 2328

c GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park South, Harlow, Essex, UK

Abstract

The solubilization capacities of micellar solutions of a series of block copolymers composed of hydrophilic poly(oxyethylene) (E) and hydrophobic poly(oxypropylene) (P), poly(oxybutylene) (B) or poly(oxyphenylethylene) (S, from styrene oxide) have been compared using the poorly water-soluble drug griseofulvin as a model solubilizate. A 1H NMR technique for determining the extent of solubilization has been developed. Considering the optimum result in each case, the amount of griseofulvin solubilized (expressed as moles griseofulvin per mole of hydrophobic units) by ES block copolymers was approximately nine times more than by EP copolymers and three times more than by EB copolymers. The mobility of the S-blocks in the cores of the ES copolymer micelles, as determined by 1H NMR spectroscopy, was sufficient to allow solubilization at ambient temperature.

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Article information

DOI
https://doi.org/10.1039/B107073H
Article type
Paper
Submitted
03 Aug 2001
Accepted
11 Sep 2001
First published
11 Oct 2001

Phys. Chem. Chem. Phys., 2001,3, 4769-4773

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The effect of hydrophobe chemical structure and chain length on the solubilization of griseofulvin in aqueous micellar solutions of block copoly(oxyalkylene)s

C. J. Rekatas, S. Mai, M. Crothers, M. Quinn, J. H. Collett, D. Attwood, F. Heatley, L. Martini and C. Booth, Phys. Chem. Chem. Phys., 2001, 3, 4769 DOI: 10.1039/B107073H

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