Issue 17, 2001

Disruption of protein–protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Abstract

Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1∶1 Cc∶1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc∶Apaf-1 complex, a key adduct in apoptosis.

Article information

Article type
Communication
Submitted
01 May 2001
Accepted
14 Jun 2001
First published
06 Aug 2001

Chem. Commun., 2001, 1580-1581

Disruption of protein–protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Y. Wei, G. L. McLendon, A. D. Hamilton, M. A. Case, C. B. Purring, Q. Lin, H. S. Park, C. Lee and T. Yu, Chem. Commun., 2001, 1580 DOI: 10.1039/B104142H

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