Issue 19, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Novel and facile catalytic synthesis of 2,4-dioxopyrido[2,3-d]pyrimidine derivatives in water

Noé Rosas,*a   Pankaj Sharma,a   Cecilio Alvarez,a   Armando Cabrera,a   Rodrigo Ramírez,a   Alejandro Delgadoa  and  Henri Arzoumanianb  

* Corresponding authors

a Instituto de Química, UNAM, C. U., Circuito Exterior, México, D. F
E-mail: noe@servidor.unam.mx
Fax: (525)6162217/6162203

b UMR6516 du CNRS, ENSSPICAM, Faculté des Sciences St Jérome, Marseille, France

Abstract

Reactions of 6-amino-1,3-dimethyluracil with substituted α-ketoalkynes using homogeneous nickel catalyst in aqueous alkaline medium, afford substituted 2,4-dioxopyrido[2,3-d]pyrimidine derivatives in quantitative yields under very mild conditions. A mechanism has been proposed for the reaction involving the nucleophilic attack of Ni(0) anion, formed in situ onto the triple bond of the substrate. All the synthesized pyrimidines were well characterized.

Graphical abstract: Novel and facile catalytic synthesis of 2,4-dioxopyrido[2,3-d]pyrimidine derivatives in water

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Article information

DOI
https://doi.org/10.1039/B101374M
Article type
Communication
Submitted
12 Feb 2001
Accepted
20 Aug 2001
First published
11 Sep 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2341-2343

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Novel and facile catalytic synthesis of 2,4-dioxopyrido[2,3-d]pyrimidine derivatives in water

N. Rosas, P. Sharma, C. Alvarez, A. Cabrera, R. Ramírez, A. Delgado and H. Arzoumanian, J. Chem. Soc., Perkin Trans. 1, 2001, 2341 DOI: 10.1039/B101374M

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