Issue 5, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl–aryl coupling reactions

Takashi Harayama,*a   Hisashi Akamatsu,a   Kana Okamura,a   Taeko Miyagoe,a   Toshihiko Akiyama,a   Hitoshi Abea  and  Yasuo Takeuchia  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama, Japan
E-mail: harayama@pharm.okayama-u.ac.jp
Fax: +81(86)2517963

Abstract

Total syntheses of trisphaeridine (3) and norchelerythrine (4), fully aromatized phenanthridine and benzo[c]phenanthridine alkaloids, were accomplished via the internal aryl–aryl coupling reaction of halo amides protected by a methoxymethyl group with the palladium reagent, followed by reduction with lithium aluminium hydride and treatment with hydrochloric acid.

Graphical abstract: Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl–aryl coupling reactions

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Article information

DOI
https://doi.org/10.1039/B008683P
Article type
Paper
Submitted
27 Oct 2000
Accepted
11 Jan 2001
First published
07 Feb 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 523-528

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Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl–aryl coupling reactions

T. Harayama, H. Akamatsu, K. Okamura, T. Miyagoe, T. Akiyama, H. Abe and Y. Takeuchi, J. Chem. Soc., Perkin Trans. 1, 2001, 523 DOI: 10.1039/B008683P

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