Issue 7, 2000
From the journal:

Analyst

Determination of thioguanine in pharmaceutical preparations by paper substrate room temperature phosphorimetry

Dong Chuan,a   Yuan Wen,b   Shuang Shaominb  and  Yang Pina  

a Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China

b Department of Chemistry, Shanxi University, Taiyuan, 030006, China.
E-mail: dc@sxu.edu.cn

Abstract

A room temperature phosphorimetric (RTP) procedure was used for the determination of 6-thioguanine (6-TG). The method is based on paper substrate room temperature phosphorimetry (PS-RTP) using indium sulfate, In2(SO4)3 as a heavy atom perturber. Various factors affecting the room temperature phosphorescence of 6-TG are discussed. The linear dynamic range for 6-TG is from 3.3 to 334.3 ng per spot with a detection limit of 4.6 ng per spot and a relative standard deviation (RSD) of 2.38%. The recovery of standard 6-TG added to commercial tablets is in the range 96.39–98.44%. The method is simple, rapid and sensitive and can be applied to the analysis of commercial tablets without interference.

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Article information

DOI
https://doi.org/10.1039/B001597K
Article type
Paper
Submitted
28 Feb 2000
Accepted
05 May 2000
First published
09 Jun 2000

Analyst, 2000,125, 1327-1330

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Determination of thioguanine in pharmaceutical preparations by paper substrate room temperature phosphorimetry

D. Chuan, Y. Wen, S. Shaomin and Y. Pin, Analyst, 2000, 125, 1327 DOI: 10.1039/B001597K

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