Issue 12, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Preparation of chiral enantiopure 2-(hydroxyalkyl)pyridine derivatives. Use of the chiral pool

Fredrik Rahm,a   Robert Stranne,a   Ulf Bremberg,a   Kerstin Nordström,a   Magnus Cernerud,a   Emmanuel Macedoa  and  Christina Moberg*a  

* Corresponding authors

a Department of Chemistry, Organic Chemistry, Royal Institute of Technology, Stockholm, Sweden

Abstract

Enantiomerically pure 2-(1-hydroxyalkyl)pyridines were prepared via reaction of 2-lithiopyridine with (R)-2,3-O-isopropylideneglyceraldehyde, methyl (S )-2-methoxypropionate and methyl (S )-2-methoxy-2-phenylacetate, obtained from D-mannitol, L-lactic acid and L-mandelic acid, respectively. 6,6′-Bis(1-hydroxyalkyl)-2,2′-bipyridines were obtained from the same naturally occurring chiral compounds and 2-bromo-6-lithiopyridine with subsequent Ni-catalysed coupling.

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Article information

DOI
https://doi.org/10.1039/B000269K
Article type
Paper
Submitted
07 Jan 2000
Accepted
07 Mar 2000
First published
18 May 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 1983-1990

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Preparation of chiral enantiopure 2-(hydroxyalkyl)pyridine derivatives. Use of the chiral pool

F. Rahm, R. Stranne, U. Bremberg, K. Nordström, M. Cernerud, E. Macedo and C. Moberg, J. Chem. Soc., Perkin Trans. 1, 2000, 1983 DOI: 10.1039/B000269K

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