Issue 1281, 1982
From the journal:

Analyst

High-performance liquid chromatographic determination of cefuroxime

Patricia A. Coomber,   Jack P. Jefferies  and  John D. Woodford  

Abstract

A rapid, precise and selective method is described for determining the purity of cefuroxime sodium. Cefuroxime is separated from closely related compounds by high-performance liquid chromatography at ambient temperature using a 10-cm column packed with 5-µm Spherisorb C6 and buffered aqueous acetonitrile as mobile phase. The eluate is monitored at 273 nm, orcinol is used as internal standard and the method has a coefficient of variation of 0.6%. The procedure is suitable for the analysis of freshly manufactured cefuroxime sodium and it also provides a reliable estimate of the potency of partly degraded samples from stability tests.

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/AN9820701451
Article type
Paper

Analyst, 1982,107, 1451-1456

Permissions

Request permissions

High-performance liquid chromatographic determination of cefuroxime

P. A. Coomber, J. P. Jefferies and J. D. Woodford, Analyst, 1982, 107, 1451 DOI: 10.1039/AN9820701451

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements