Catalytic asymmetric aldol reactions in water without the use of organic solvents have been carried out by using a combination of copper bis(dodecyl sulfate), a chiral bis(oxazoline) ligand, and a carboxylic acid to afford the desired products in high yields with good enantiomeric excesses.
S. Kobayashi, Y. Mori, S. Nagayama and K. Manabe, Green Chem., 1999, 1, 175 DOI: 10.1039/A904439F
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