Issue 16, 1997

3,4-Bis(trimethylsilyl)-1H-pyrrole: a versatile building block for unsymmetrically 3,4-disubstituted pyrroles

Abstract

3,4-Bis(trimethylsilyl)-1H-pyrrole 1c functions as a versatile building block for the construction of unsymmetrically 3,4-disubstituted pyrroles through the use of stepwise regiospecific ipso mono-halogenation, Sonogashira cross-coupling reactions and Suzuki cross-coupling reactions; the advantages of this strategy lie in its stepwise manner as well as in its prospect of yielding 3,4-disubstituted pyrroles with diverse substitution patterns.

Article information

Article type
Paper

Chem. Commun., 1997, 1515-1516

3,4-Bis(trimethylsilyl)-1H-pyrrole: a versatile building block for unsymmetrically 3,4-disubstituted pyrroles

H. Chan, P. Chan, J. Liu and H. N. C. Wong, Chem. Commun., 1997, 1515 DOI: 10.1039/A703921B

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