Issue 4, 1997
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of conformationally constrained phenylalanine analogues via 7-, 8- and 9-endo Heck cyclisations

Susan E. Gibson (née Thomas),   Nathalie Guillo,   Richard J. Middleton,   Audrey Thuilliez  and  Matthew J. Tozer  

Abstract

The novel conformationally constrained phenylalanine analogues 2,3,4,5-tetrahydro-1H-3-benzazepine-2-carboxylic acid (Sic) 1, 1,2,3,4,5,6-hexahydro-3-benzazocine-2-carboxylic acid (Hic) 2 and 2,3,4,5,6,7-hexahydro-1H-3-benzazonine-2-carboxylic acid (Nic) 3 have been synthesised from commercially available 2-iodobenzyl alcohol in 20, 18 and 22% overall yield respectively via 7-, 8- and 9-endo Heck cyclisations.

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Article information

DOI
https://doi.org/10.1039/A605286J
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1997, 447-456

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Synthesis of conformationally constrained phenylalanine analogues via 7-, 8- and 9-endo Heck cyclisations

S. E. Gibson (née Thomas), N. Guillo, R. J. Middleton, A. Thuilliez and M. J. Tozer, J. Chem. Soc., Perkin Trans. 1, 1997, 447 DOI: 10.1039/A605286J

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