4,5-Dihydro-1-benzoxepin-3(2H)-one, N-substituted 2,3-dihydro-1,5-benzoxazepin-4(5H)-ones, and related compounds
Abstract
The preparation of 4,5-dihydro-1-benzoxepin-3(2H)-one and its conversion into 2,3,4,5-tetrahydro-1-benzoxepin-3-amines and related compounds are reported. Ring cleavage of 2,3-dihydro-1,5-benzoxazepin-4(5H)-one to give an acrylamide readily occurs when N-alkylation is attempted. Methods are described for the preparation of some 5-substituted 2,3-dihydro-1,5-benzoxazepin-4(5H)-ones.