In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

Shifen Li; Hua Zhang; Jieqi Xie; Zhaoyi Wang; Kai Wang; Zihe Zhai; Jie Ding; Shuqin Wang; Liyin Shen; Jun Wen; Yi-Da Tang; Huanan Wang; Yang Zhu; Changyou Gao

doi:10.1039/D3MH00594A

In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy†

Shifen Li,^a Hua Zhang,^c Jieqi Xie,^a Zhaoyi Wang,^a Kai Wang,^a Zihe Zhai,^a Jie Ding,^a Shuqin Wang,^a Liyin Shen,^a Jun Wen,^d Yi-Da Tang,^d Huanan Wang,^c Yang Zhu*^a and Changyou Gao

*^ab

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* Corresponding authors

^a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: zhuyang@zju.edu.cn, cygao@zju.edu.cn

^b Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312099, China

^c College of Animal Science, Zhejiang University, Hangzhou 310058, China

^d Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Abstract

Advanced elastomers are highly in demand for the fabrication of medical devices for minimally invasive surgery (MIS). Herein, a shape memory and self-healing polyurethane (PCLUSe) composed of semi-crystalline poly(ε-caprolactone) (PCL) segments and interchangeable and antioxidative diselenide bonds was designed and synthesized. The excellent shape memory of PCLUSe contributed to the smooth MIS operation, leading to less surgical wounds than in the case of sternotomy. The diselenide bonds of PCLUSe contributed to the rapid self-healing under 405 nm irradiation within 60 s, and the alleviation of tissue oxidation post injury. After being delivered through a 10 mm diameter trocar onto a beating canine heart by MIS, two shape-recovered PCLUSe films self-assembled (self-healing) into a larger single patch (20 × 10 × 0.2 mm³) under the trigger of laser irradiation in situ, which could efficiently overcome the limited-size problem within MIS and meet a larger treatment area. The diselenide bonds in the PCLUSe cardiac patches protected the myocardium under oxidative stress post myocardial infarction (MI), and significantly maintained the cardiac functions.

This article is part of the themed collection: Materials Horizons HOT Papers

Materials Horizons

In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy†

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In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

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