Nanozymes, a class of synthetic nanomaterials possessing enzymatic catalytic properties, exhibit distinct advantages such as exceptional stability and cost-effectiveness. Among them, metal–organic framework (MOF)-based nanozymes have garnered significant attention due to their large specific surface area, tunable pore size and uniform structure. MOFs are porous crystalline materials bridged by inorganic metal ions/clusters and organic ligands, which hold immense potential in the fields of catalysis, sensors and drug carriers. The combination of MOFs with diverse nanomaterials gives rise to various types of MOF-based nanozyme, encompassing original MOFs, MOF-based nanozymes with chemical modifications, MOF-based composites and MOF derivatives. It is worth mentioning that the metal ions and organic ligands in MOFs are perfectly suited for designing oxidoreductase-like nanozymes. In this review, we intend to provide an overview of recent trends and progress in MOF-based nanozymes with oxidoreductase-like activity. Furthermore, the current obstacles and prospective outlook of MOF-based nanozymes are proposed and briefly discussed. This comprehensive analysis aims to facilitate progress in the development of novel MOF-based nanozymes with oxidoreductase-like activity while serving as a valuable reference for scientists engaged in related disciplines.