Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1

Wenjing Wu; Xing Li; Lingyu Zhao; Shumu Li; Juanjuan Han; Yangyang Zhang; Zhenwen Zhao

doi:10.1039/D2CC01654K

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Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1†

Wenjing Wu,^ab Xing Li,^ab Lingyu Zhao,^ab Shumu Li,^a Juanjuan Han,^a Yangyang Zhang*^ab and Zhenwen Zhao

*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: zhangyy@iccas.ac.cn, zhenwenzhao@iccas.ac.cn

^b University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in a broad range of human tumors but remains difficult to study. Herein, we report a novel two-photon fluorescent probe with NIR emission for NQO1 detection. The probe demonstrated superior analytical performance with a large Stokes shift and deep tissue penetration.

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DOI: https://doi.org/10.1039/D2CC01654K
Article type: Communication
Submitted: 23 Mar 2022
Accepted: 12 Apr 2022
First published: 19 Apr 2022

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Chem. Commun., 2022,58, 5634-5637

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Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1

W. Wu, X. Li, L. Zhao, S. Li, J. Han, Y. Zhang and Z. Zhao, Chem. Commun., 2022, 58, 5634 DOI: 10.1039/D2CC01654K

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Chemical Communications

Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1†

Abstract

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Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1

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