Issue 2, 2022
From the journal:

RSC Advances

Improvement of cytotoxicity and necrosis activity of ganoderic acid a through the development of PMBN-A.Her2-GA as a targeted nano system

P. Motamed Fath, ORCID logo *a   M. Rahimnejad,bc   S. Moradi-kalbolandi,d   B. Ebrahimi Hosseinzadeha  and  T. Jamshidnejad-tosaramandanie  

* Corresponding authors

a Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
E-mail: puria.motamed@yahoo.com
Tel: +98-919-4500 621

b Biomedical Engineering Institute, School of Medicine, Université de Montréal, Montreal, Canada

c Research Centre, Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal, Canada

d Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

e Nano Biotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

Abstract

The targeting nano carriers have been promptly proposed to overcome the current obstacles in conventional chemotherapy approaches for cancer. Currently, PMBN (poly[MPC-co-(BMA)-co-(MEONP)]), is considered as a promising amphiphilic polymer that could be easily targeted and conjugated to hydrophobic substances with low bioavailability. To target breast cancer cells overexpressing human epidermal receptor 2 (HER2) receptors, anti-HER2 monoclonal antibody (A.Her2) was conjugated to PMBN and afterward loaded with ganoderic acid A (GA-A) as an anti-cancer metabolite. The efficacy of conjugation and loading was reasonably favourable. The rod shape of the polymer with a size of approximately 160 ± 30 nm was confirmed. Our results indicated that PMBN-A.Her2-GA is an anionic nanostructure with an appropriate form and capable of being applied in cancer therapy. Subsequently, cytotoxicity analysis revealed an improved anti-proliferative effect of GA-A.

Graphical abstract: Improvement of cytotoxicity and necrosis activity of ganoderic acid a through the development of PMBN-A.Her2-GA as a targeted nano system

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Article information

DOI
https://doi.org/10.1039/D1RA06488F
Article type
Paper
Submitted
28 Aug 2021
Accepted
11 Dec 2021
First published
05 Jan 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 1228-1237

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Improvement of cytotoxicity and necrosis activity of ganoderic acid a through the development of PMBN-A.Her2-GA as a targeted nano system

P. Motamed Fath, M. Rahimnejad, S. Moradi-kalbolandi, B. Ebrahimi Hosseinzadeh and T. Jamshidnejad-tosaramandani, RSC Adv., 2022, 12, 1228 DOI: 10.1039/D1RA06488F

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