SCHEDULED MAINTENANCE
Synthesis of 5,7-diarylindoles via Suzuki–Miyaura coupling in water†
Vijayaragavan
Elumalai 
a
and
Jørn H.
Hansen
*a
a
and
Jørn H.
Hansen
*a
Abstract
The synthesis of novel 5,7-diaryl and diheteroaryl indoles has been explored via efficient double Suzuki–Miyaura coupling. The method notably employs a low catalyst loading of Pd(PPh3)4 (1.5 mol%/coupling) and water as the reaction solvent to obtain 5,7-diarylated indoles without using N-protecting groups in up to 91% yield. The approach is also suitable for N-protected and 3-substituted indoles and constitutes an important green and convenient arylation strategy for the benzenoid ring of indoles. The synthesized diarylindoles are fluorescent.
- This article is part of the themed collections: Synthetic methodology in OBC and Catalysis & biocatalysis in OBC
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