Ultrafast 2D 1H–1H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

Kawarpal Singh; Corentin Jacquemmoz; Patrick Giraudeau; Lucio Frydman; Jean-Nicolas Dumez

doi:10.1039/D1CC03079E

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Ultrafast 2D ¹H–¹H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures†

Kawarpal Singh,

^a Corentin Jacquemmoz,

^b Patrick Giraudeau,

^b Lucio Frydman

*^a and Jean-Nicolas Dumez

*^b

Author affiliations

* Corresponding authors

^a Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel
E-mail: lucio.frydman@weizmann.ac.il

^b Université de Nantes, CNRS, CEISAM UMR6230, Nantes F-44000, France
E-mail: jean-nicolas.dumez@univ-nantes.fr

Abstract

We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.

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Article information

DOI: https://doi.org/10.1039/D1CC03079E
Article type: Communication
Submitted: 10 Jun 2021
Accepted: 15 Jul 2021
First published: 15 Jul 2021
This article is Open Access

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Chem. Commun., 2021,57, 8035-8038

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Ultrafast 2D ¹H–¹H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

K. Singh, C. Jacquemmoz, P. Giraudeau, L. Frydman and J. Dumez, Chem. Commun., 2021, 57, 8035 DOI: 10.1039/D1CC03079E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Communications