Issue 5, 2020
From the journal:

Materials Advances

Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity†

Aneeqa Nawaz,a   Shaher Bano,a   Muhammad Yasir,a   Abdul Wadooda  and  Muhammad Atiq Ur Rehman ORCID logo *a  

* Corresponding authors

a Department of Materials Science and Engineering, Institute of Space Technology Islamabad, 1, Islamabad Highway, Islamabad, Pakistan
E-mail: atique1.1@hotmail.com

Abstract

Bioactive and antibacterial coatings were developed and characterized in this study. Chitosan/gelatin/Ag–Mn doped mesoporous bioactive glass nanoparticles (Ag–Mn MBGNs) composite coatings (of 5–6 μm thickness) were deposited using electrophoretic deposition (EPD) on PEEK/bioactive glass (BG) layers (of 60–70 μm thickness), which had been deposited by EPD onto stainless steel. The chitosan/gelatin/Ag–Mn MBGNs composite coatings deposited on PEEK/BG layers were optimized by the Taguchi design of experiment (DoE) approach; the resulting microstructure, composition, in vitro bioactivity, antibacterial activity, and cytocompatibility were investigated. Scanning electron microscopy (SEM) images confirmed the deposition of Ag–Mn MBGNs on the surface of PEEK/BG layers. Energy dispersive spectroscopy (EDX) confirmed the presence of Mn and Ag, which were embedded in chitosan/gelatin (top layer). The presence of BG particles in the PEEK/BG layer and Ag–Mn MBGNs in the top layer allows the multi-structured coatings to form apatite like crystals upon immersion in simulated body fluid (SBF). Moreover, the release of silver ions from the top layer provided an antibacterial effect against Escherichia coli and Staphylococcus carnosus.

Graphical abstract: Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity

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Article information

DOI
https://doi.org/10.1039/D0MA00325E
Article type
Paper
Submitted
18 May 2020
Accepted
01 Jul 2020
First published
02 Jul 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2020,1, 1273-1284

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Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity

A. Nawaz, S. Bano, M. Yasir, A. Wadood and M. A. Ur Rehman, Mater. Adv., 2020, 1, 1273 DOI: 10.1039/D0MA00325E

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