Issue 58, 2019
From the journal:

Chemical Communications

A nanoscale iron catalyst for heterogeneous direct N- and C-alkylations of anilines and ketones using alcohols under hydrogen autotransfer conditions†

Madhu Nallagangula,a   Chandragiri Sujatha,a   Venugopal T. Bhat*b  and  Kayambu Namitharan ORCID logo *a  

* Corresponding authors

a Organic Synthesis and Catalysis Laboratory, SRM Research Institute, SRM IST, Chennai, India
E-mail: namitharan.k@res.srmuniv.ac.in

b Department of Chemistry, SRM IST, Chennai, India
E-mail: venu.iitkgp@gmail.com

Abstract

Here, we report a commercially available nanoscale Fe catalyst for heterogeneous direct N- and C-alkylation reactions of anilines and methyl ketones with alcohols. A hydrogen autotransfer mechanism has been found to operate in these reactions by deuterium labelling studies. In addition, dehydrogenative quinoline synthesis has been demonstrated from amino benzyl alcohols and acetophenones.

Graphical abstract: A nanoscale iron catalyst for heterogeneous direct N- and C-alkylations of anilines and ketones using alcohols under hydrogen autotransfer conditions

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Article information

DOI
https://doi.org/10.1039/C9CC04120F
Article type
Communication
Submitted
28 May 2019
Accepted
26 Jun 2019
First published
26 Jun 2019

Chem. Commun., 2019,55, 8490-8493

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A nanoscale iron catalyst for heterogeneous direct N- and C-alkylations of anilines and ketones using alcohols under hydrogen autotransfer conditions

M. Nallagangula, C. Sujatha, V. T. Bhat and K. Namitharan, Chem. Commun., 2019, 55, 8490 DOI: 10.1039/C9CC04120F

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