Issue 39, 2018
From the journal:

Dalton Transactions

Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents†

David O. Abe,a   Arvin Eskandaria  and  Kogularamanan Suntharalingam ORCID logo *a  

* Corresponding authors

a Department of Chemistry, King's College London, London, UK
E-mail: kogularamanan.suntharalingam@kcl.ac.uk

Abstract

We report a novel series of cobalt(III)-polypridyl complexes, 4–6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

Graphical abstract: Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents

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Article information

DOI
https://doi.org/10.1039/C8DT03448F
Article type
Communication
Submitted
24 Aug 2018
Accepted
10 Sep 2018
First published
10 Sep 2018

Dalton Trans., 2018,47, 13761-13765

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Diflunisal-adjoined cobalt(III)-polypyridyl complexes as anti-cancer stem cell agents

D. O. Abe, A. Eskandari and K. Suntharalingam, Dalton Trans., 2018, 47, 13761 DOI: 10.1039/C8DT03448F

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