A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant 89Zr-immuno-PET agents

Nikunj B. Bhatt; Darpan N. Pandya; Stephanie Rideout-Danner; Howard D. Gage; Frank C. Marini; Thaddeus J. Wadas

doi:10.1039/C8DT01841C

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A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant ⁸⁹Zr-immuno-PET agents†

Nikunj B. Bhatt,‡^a Darpan N. Pandya,

‡^a Stephanie Rideout-Danner,^b Howard D. Gage,

^b Frank C. Marini^ac and Thaddeus J. Wadas

*^a

Author affiliations

* Corresponding authors

^a Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
E-mail: twadas@wakehealth.edu

^b Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA

^c Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC 27157, USA

Abstract

Zirconium-89 is currently being used in numerous clinical trials involving monoclonal antibodies and positron emission tomography. This report describes a revised strategy that reduces preparation time while increasing the specific activity of clinically relevant immuno-PET agents. Additionally, it demonstrates that n-acetyl-L-cysteine acts as a superior radioprotective agent that improves long-term stability without compromising antigen affinity in vivo.

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Article information

DOI: https://doi.org/10.1039/C8DT01841C
Article type: Paper
Submitted: 07 May 2018
Accepted: 12 Aug 2018
First published: 04 Sep 2018

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Dalton Trans., 2018,47, 13214-13221

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A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant ⁸⁹Zr-immuno-PET agents

N. B. Bhatt, D. N. Pandya, S. Rideout-Danner, H. D. Gage, F. C. Marini and T. J. Wadas, Dalton Trans., 2018, 47, 13214 DOI: 10.1039/C8DT01841C

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Dalton Transactions