Issue 84, 2018
From the journal:

Chemical Communications

Variation in the Yaa position of collagen peptides containing azaGlycine†

Samuel D. Melton ORCID logo a  and  David M. Chenoweth ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA
E-mail: dcheno@sas.upenn.edu

Abstract

Herein, we report the systematic investigation of amino acid variation in the Yaa position of collagen peptides containing an adjacent azaGlycine residue. We demonstrate the reliability of azaGlycine as a glycine replacement and provide a sequence independent strategy for stabilizing the triple helical assembly of collagen peptides.

Graphical abstract: Variation in the Yaa position of collagen peptides containing azaGlycine

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Article information

DOI
https://doi.org/10.1039/C8CC06372A
Article type
Communication
Submitted
04 Aug 2018
Accepted
28 Sep 2018
First published
05 Oct 2018

Chem. Commun., 2018,54, 11937-11940

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Variation in the Yaa position of collagen peptides containing azaGlycine

S. D. Melton and D. M. Chenoweth, Chem. Commun., 2018, 54, 11937 DOI: 10.1039/C8CC06372A

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