MRI and luminescence detection of Zn2+ with a lanthanide complex–zinc finger peptide conjugate

Manon Isaac; Agnès Pallier; Frédéric Szeremeta; Pierre-Alain Bayle; Laurent Barantin; Célia S. Bonnet; Olivier Sénèque

doi:10.1039/C8CC04366C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

MRI and luminescence detection of Zn²⁺ with a lanthanide complex–zinc finger peptide conjugate†

Manon Isaac,^a Agnès Pallier,^b Frédéric Szeremeta,^b Pierre-Alain Bayle,^c Laurent Barantin,^d Célia S. Bonnet

*^b and Olivier Sénèque*^a

Author affiliations

* Corresponding authors

^a Univ. Grenoble Alpes, CNRS, CEA, BIG, LCBM (UMR 5249), Grenoble, France
E-mail: olivier.seneque@cea.fr

^b Centre de Biophysique Moléculaire, UPR CNRS 4301, Université d'Orléans, F-45071 Orléans, France
E-mail: celia.bonnet@cnrs.fr

^c Univ. Grenoble Alpes, CEA, INAC, MEM, F-38000 Grenoble, France

^d UMR 1253, iBrain, Université de Tours, Tours, France

Abstract

A bioinspired probe based on a zinc finger peptide functionalized by a lanthanide(III)-DOTA monoamide complex turns out to be active for both luminescence and MRI detection of Zn²⁺, depending on the lanthanide cation. A mechanism for MRI-based detection is proposed.

Download options Please wait...

Supplementary files

Supplementary information PDF (1559K)

Article information

DOI: https://doi.org/10.1039/C8CC04366C
Article type: Communication
Submitted: 31 May 2018
Accepted: 08 Jun 2018
First published: 18 Jun 2018

Download Citation

Chem. Commun., 2018,54, 7350-7353

Permissions

Request permissions

MRI and luminescence detection of Zn²⁺ with a lanthanide complex–zinc finger peptide conjugate

M. Isaac, A. Pallier, F. Szeremeta, P. Bayle, L. Barantin, C. S. Bonnet and O. Sénèque, Chem. Commun., 2018, 54, 7350 DOI: 10.1039/C8CC04366C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications