A review of fluorescent signal-based lateral flow immunochromatographic strips

Xiaoqun Gong; Jin Cai; Bo Zhang; Qian Zhao; Jiafang Piao; Weipan Peng; Weichen Gao; Dianming Zhou; Miao Zhao; Jin Chang

doi:10.1039/C7TB01049D

A review of fluorescent signal-based lateral flow immunochromatographic strips

Xiaoqun Gong,†^a Jin Cai,†^a Bo Zhang,^a Qian Zhao,^a Jiafang Piao,^a Weipan Peng,^a Weichen Gao,^a Dianming Zhou,^bc Miao Zhao^b and Jin Chang*^a

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* Corresponding authors

^a School of Life Sciences, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, China
E-mail: jinchang@tju.edu.cn

^b Department of Toxicology, Tianjin Centers for Disease Control and Prevention, China

^c State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China

Abstract

Fluorescent signal-based lateral flow immunochromatographic strips (FLFICS) have received great expectations since they effectively improve detection sensitivity with quantitative analysis, and still retain the advantages of simplicity, rapidness, and portability of a common lateral flow immunochromatographic strip (LFICS). Diverse fluorescent reporters have promoted development of FLFICS, such as fluorescent dyes, quantum dots (QDs), an up-converting phosphor (UCP), lanthanide labels, and other fluorescence nanoparticles. In this work, we discuss the different fluorescent reporters applied with LFICS and their unique properties as well as signal amplification strategies helping to enhance detection performance. Benefitting from these sensitive and accurate fluorescent labels, FLFICS commendably satisfies requirements for detecting different disease biomarkers in medical diagnosis, strict supervision of food safety, and water pollution. This work also gives a short introduction to trends in the development of future FLFICS technology.

This article is part of the themed collection: Recent Review Articles

Journal of Materials Chemistry B

A review of fluorescent signal-based lateral flow immunochromatographic strips

Abstract

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A review of fluorescent signal-based lateral flow immunochromatographic strips

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