Surface functional DNA density control by programmable molecular defects

Chong-You Chen; Chang-Ming Wang; Pai-Shan Chen; Wei-Ssu Liao

doi:10.1039/C7CC09908H

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Surface functional DNA density control by programmable molecular defects†

Chong-You Chen,^a Chang-Ming Wang,^a Pai-Shan Chen^b and Wei-Ssu Liao

*^a

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* Corresponding authors

^a Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan
E-mail: wsliaochem@ntu.edu.tw

^b Department and Graduate Institute of Forensic Medicine, National Taiwan University, Taipei 10002, Taiwan

Abstract

Programmable surface-patterned functional DNA density is achieved via manipulation of molecular-level defects through chemical lift-off lithography. Artificial SAM defects are well-tunable by a contact-induced reaction, enabling molecular environment guidance and DNA insertion to be spatially and quantitatively addressable. This straightforward molecular density control creates an advanced avenue toward fabricating multiplexed bioactive substrates.

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Article information

DOI: https://doi.org/10.1039/C7CC09908H
Article type: Communication
Submitted: 28 Dec 2017
Accepted: 13 Feb 2018
First published: 14 Feb 2018

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Chem. Commun., 2018,54, 4100-4103

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Surface functional DNA density control by programmable molecular defects

C. Chen, C. Wang, P. Chen and W. Liao, Chem. Commun., 2018, 54, 4100 DOI: 10.1039/C7CC09908H

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Chemical Communications

Surface functional DNA density control by programmable molecular defects†

Abstract

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Surface functional DNA density control by programmable molecular defects

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