Issue 91, 2016, Issue in Progress
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RSC Advances

Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins†

Xiaomei Li,a   Jing Zhu,b   Guoyin Shi,b   Mingwei Sun,a   Zhixing Guo,a   Haoxin Wang,b   Chunhua Lu*a  and  Yuemao Shen*ab  

* Corresponding authors

a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, P. R. China
E-mail: ahua0966@sdu.edu.cn
Tel: +86-531-88382108

b State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Jinan, Shandong 250100, P. R. China
E-mail: yshen@sdu.edu.cn
Tel: +86-531-88382108

Abstract

Seven new ansatrienin-type ansamycins, namely, ansatrienols B–H (1–7), along with four known ones (8–11), were isolated from the strain Streptomyces sp. XZQH13OEΔastC constructed by deleting the astC gene responsible for the assembly of the N-cyclohexanoyl D-alanyl side chain. Their structures were determined by analysis of the 1D and 2D NMR spectroscopic data and high-resolution ESIMS. This study revealed the diverse post-PKS modifications during the biosynthesis of ansatrienins.

Graphical abstract: Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins

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Article information

DOI
https://doi.org/10.1039/C6RA19036G
Article type
Paper
Submitted
27 Jul 2016
Accepted
27 Aug 2016
First published
31 Aug 2016

RSC Adv., 2016,6, 88571-88579

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Deletion of the side chain assembly reveals diverse post-PKS modifications in the biosynthesis of ansatrienins

X. Li, J. Zhu, G. Shi, M. Sun, Z. Guo, H. Wang, C. Lu and Y. Shen, RSC Adv., 2016, 6, 88571 DOI: 10.1039/C6RA19036G

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