Issue 67, 2016

Morita–Baylis–Hillman reaction in eutectic solvent under aqueous medium

Abstract

A series of deep eutectic solvents (DESs) based on choline chloride were prepared and used in the Morita–Baylis–Hillman (M–B–H) reaction. Research showed that the composite solvent (1ChCl/2Gly DES–H2O) is a very effective solvent media for all substrates tested. Under the mild reaction conditions, DABCO catalyzed M–B–H reactions proceed very quickly and efficiently. It is particularly important that the solid M–B–H adducts suspended in the reaction system at the end of the reaction, which can be obtained by simple filtering. Such simple product processing is not reported in the previous literature. The composite solvent (1ChCl/2Gly DES–H2O) was reused directly without any activation process. After six cycles, the yields almost remained unchanged. This protocol has notable advantages such as low cost, ease of work-up and reuse of DES conveniently, which could contribute to the development of new solvent system for use in continuous chemical processes.

Graphical abstract: Morita–Baylis–Hillman reaction in eutectic solvent under aqueous medium

Supplementary files

Article information

Article type
Paper
Submitted
22 Feb 2016
Accepted
17 Jun 2016
First published
20 Jun 2016

RSC Adv., 2016,6, 62778-62784

Morita–Baylis–Hillman reaction in eutectic solvent under aqueous medium

S. Zhao, H. Zhi, M. Zhang, Q. Yan, J. Fan and J. Guo, RSC Adv., 2016, 6, 62778 DOI: 10.1039/C6RA04710F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements