Issue 41, 2016
From the journal:

RSC Advances

Hyaluronic acid-coated poly(d,l-lactide) (PDLLA) nanofibers prepared by electrospinning and coating

J. J. Ahire,a   D. Robertson,b   D. P. Neveling,a   A. J. van Reenenb  and  L. M. T. Dicks*a  

* Corresponding authors

a Department of Microbiology, University of Stellenbosch, 7602 Matieland, Stellenbosch, South Africa
E-mail: LMTD@sun.ac.za
Fax: +27 21 808 5846
Tel: +27 21 808 5849

b Department of Chemistry and Polymer Science, University of Stellenbosch, 7602 Matieland, Stellenbosch, South Africa

Abstract

Hyaluronic acid nanofibers (HA/PDLLA) were prepared by coating electrospun poly(D,L-lactide) (PDLLA) with different concentrations of HA. Highest concentration of HA deposited onto PDLLA nanofibers (17% per weight) were obtained by coating with 0.3% (w/v) HA. Coating with 0.5% (w/v) and 0.1% (w/v) HA yielded a deposit of 3.8% and 3% per weight, respectively. All nanofibers were 300–400 nm in diameter and microscopically homogeneous in structure, with traces of HA clearly visible on the surface and in-between the fibers. Examination of the nanofibers with Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) revealed changes in the properties of the nanofibers when coated with 0.3% (w/v) HA. Release of HA from HA/PDLLA fibers were at a linear and constant rate. One possible application for HA/PDLLA is the coating of surfaces, such as medical implants, to prevent secondary microbial infections during recovery from surgery.

Graphical abstract: Hyaluronic acid-coated poly(d,l-lactide) (PDLLA) nanofibers prepared by electrospinning and coating

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Article information

DOI
https://doi.org/10.1039/C6RA01996J
Article type
Paper
Submitted
22 Jan 2016
Accepted
01 Apr 2016
First published
04 Apr 2016
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2016,6, 34791-34796

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Hyaluronic acid-coated poly(D,L-lactide) (PDLLA) nanofibers prepared by electrospinning and coating

J. J. Ahire, D. Robertson, D. P. Neveling, A. J. van Reenen and L. M. T. Dicks, RSC Adv., 2016, 6, 34791 DOI: 10.1039/C6RA01996J

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