Issue 23, 2015
From the journal:

Organic & Biomolecular Chemistry

Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs†

Yong Zheng,a   Wei-Bin Song,a   Shu-Wei Zhanga  and  Li-Jiang Xuan*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China
E-mail: ljxuan@mail.shcnc.ac.cn

Abstract

A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C–H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.

Graphical abstract: Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

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Article information

DOI
https://doi.org/10.1039/C5OB00601E
Article type
Communication
Submitted
27 Mar 2015
Accepted
07 May 2015
First published
07 May 2015

Org. Biomol. Chem., 2015,13, 6474-6478

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Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

Y. Zheng, W. Song, S. Zhang and L. Xuan, Org. Biomol. Chem., 2015, 13, 6474 DOI: 10.1039/C5OB00601E

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